Sabinsa's Curcumin C3 Complex® And BioPerine® Combination Used In Published Study On Metabolic Syndrome
Another significant study on the combination of Curcumin C3 Complex® and BioPerine®,  Lipid-modifying effects of adjunctive therapy with curcuminoids–piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial, by researchers at University of Medical Sciences, Mashhad, Iran, has been published in Complementary Therapies in Medicine 2014;  22(5): 851-857. 


Sabinsa's BioPerine® Validated In Resveratrol Pre-Clincal Study
A Study published in the August Volume of Molecular Nutrition & Food Research (Special Issue: Resveratrol - Current Status and Outlook) enttitled Enhancing the bioavailability of resveratrol by combining with piperline, found that the absorption of resveratrol was signifcantly increased when combined with piperine (black pepper extract) in lab mice.


Cover Story: BioPerine®
BioPerine® is a standardized extract from the fruits of Piper nigrum L. (black pepper) or Piper longum L. (long pepper). It contains a minimum piperine content of 95% compared to the 3­9% and 3­5% found in raw forms of Piper nigrum and Piper longum,  respectively. BioPerine® may be coadministered with various nutrients for both human and animal health.


Sabinsa's BioPerine® Patent Confirmed
The US Patent and Trademark Office has completed a formal review of Sabinsa Corporation's patent for black pepper extract,  BioPerine®,  and has found the intellectual property to be valid.

The corporation announced in November it was taking legal action against DNP International for allegedly infringing patents protecting the use of its  BioPerine® and Forslean extracts. Respect for intellectual property is critical in sustaining the spirit of research and innovation and in making these efforts economically worthwhile. Sabinsa Corporation has built a sizeable intellectual property portfolio and actively advocates the protection of intellectual property.



Product Focus : Third U.S Patent Granted
Sabinsa Corporation has been granted its third patent by the U.S. Patent and Trademark Office on the use of its trademarked black pepper extract  BioPerine®. The current patent, U.S. Patent No. 5,972,382 (October 26, 1999) is a divisional application of U.S. Patent No. 5,744,161 (1998) and U.S. Patent No. 5,536,506 (1996). It discusses compositions and methods for increasing nutrient bioavailability, improving gastrointestinal (GI) absorption and systemic utilization of nutritional materials,  increasing nutrient induced thermogenesis,  and increasing lean body mass by the administration of one or more nutritional materials with a bioavailability enhancing amount of piperine.


BioPerine®: Mechanism of Action

A thermonutrient like Sabinsa’s multi­patented BioPerine® (min. 98% piperine content) can enhance the process of nutrient absorption by enhancing thermogenesis. The leading theory of food­ induced thermogenesis relates to the autonomous nervous system. The autonomous nervous system is represented by two main receptors in the gastrointestinal tract, the alpha and beta adrenergic receptors.

Most of the food or thermonutrient­induced thermogenesis is facilitated by beta receptors, which include a compound known as cyclic adenosine 3’, 5’ monophosphate (cAMP). The role of cAMP as a "second messenger" to the hormonal and enzymatic actions in the body is well recognized. When thermogenesis occurs, the demand for fresh nutrients to sustain the metabolic processes rapidly increases.



BioPerine®: New U.S. Patent  
Sabinsa Corporation was assigned a second patent on its trademarked standardized black pepper extract, BioPerine®,  by the U.S. Patents and Trademarks office.

The first patent on the use of BioPerine® as an enhancer of nutrient bioavailability, (U.S. Patent 5,536,506) was issued in 1996. Patent 5,744,161 dated April 28, 1998,  covers the use of piperine as a bioavailability enhancer for a broader range of nutritional supplements.

The salient features of the oral, topical and parenteral compositions with piperine described in the patent, include increased gastrointestinal absorption and improved transfer of nutrients / biological compounds through various biological membrane barriers in the body,  as well as enhanced systemic utilization of these compounds. The patent also describes a new process for the extraction and purification of piperine.



BioPerine®: Bioavailability Enhancer 
The 1996 patent awarded by the U.S. Patent & Trademark Office to Sabinsa Corporation on the use of the trade marked extract of black pepper,  BioPerine® (containing at least 95% piperine) has been much in the news recently, on account of misinformation generated by oleoresin maufacturers who tried to sell the product for its patented use. Critics have made a totally false accusation that the patent interferes with the export of black pepper and its products from India.

The patent refers to the USE OF PIPERINE,  specifically to increase the bioavallability of compounds such as vitamins, amino acids and minerals in nutritional supplement formulations. It is not a product patent and does not infringe upon the export of black pepper,  piperine or pepper oleoresin from India, Indonesia or Sri Lanka. Based on documented research and detailed clinical studies, the patent only serves to render credibility to the use of a piperine as an enhancer of nutrient bioavailability.


Sabinsa Corporation은 영양, 화장품, 제약 및 식품 산업을 위한 허브 추출물, 기능성화장품원료, 미네랄, 식이 보충제 및 특수 정제 화학물질의 제조, 공급 및 마케팅을 하는 업체입니다. Read more..
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